LiterView

beta

Natural Sciences›Biology›cell-biology

Rete ridges form via evolutionarily distinct mechanisms in mammalian skin

Sean ThompsonWashington State University

Violet S. YapleWashington State University

Gabriella H. SearleWashington State University

Quan M PhanWashington State University

Jasson MakkarWashington State University

Xiangzheng ChengWuhan University

Ruiqi LiuUniversity of California, Irvine

Anna Pulawska-CzubUniversity of Warsaw

Corin YankeWashington State University

Natalie M. WilliamsWashington State University

Nature·February 4, 2026·1 citations

View Paper

Abstract

The loss of fur during human evolution has long mystified scientists and the public 1–5 . Reduced hair density coincides with acquisition of epidermal rete ridges, the developmental timing and molecular mechanisms of which are poorly understood despite their prominence in humans 1,6–9 . Examination of human and pig skin development has shown that rete ridges form through a mechanism independent from those of hair follicles 10,11 and sweat glands 3,4,12–15 by establishing interconnected epidermal invaginations. Here we document the occurrence of rete ridges across Mammalia, including in grizzly bears and dolphins, and show that neonatal pig wounds can regenerate them de novo. Multispecies spatiotemporal transcriptomics identifies significant signalling interactions between epidermal and dermal cells during rete ridge morphogenesis, particularly through bone morphogenetic proteins (BMP). We also demonstrate that mouse fingerpad skin forms rete ridges and functionally requires epidermal BMP signalling. We propose that evolution of rete ridges in mammalian skin involved replacement of the molecular program for formation of discrete microscopic appendages, including hair follicles and sweat glands, with a distinct program for the interconnected appendage network. Broad epidermal activation of BMP is required for the development of rete ridge networks organized around underlying dermal pockets. Understanding rete ridge mechanisms may enable development of therapeutic approaches to regenerate epidermal appendages lost during wounding or disease in humans.

Comments (0)

No comments yet. Be the first to share your thoughts!