Initiation of Proton Pump Inhibitors is Associated with Gut Microbiome Diversity and Composition: a new-user target trial emulation within the Baltimore Longitudinal Study of Aging

Bruno BohnColorado School of Public Health

Curtis TilvesColorado School of Public Health

Lea ZillichNational Institute on Aging

Luigi FerrucciNational Institute on Aging

Chee W ChiaInstitute on Aging

Adam P. SpiraJohns Hopkins University

Noel T. MuellerColorado School of Public Health

American Journal of Epidemiology·February 5, 2026

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